Biacore突出的灵敏度为小分子药物的发现和开发提供了高效的解决方案，帮助筛选和发现高可信的、有成药性的小分子化合物，排除非特异性结合和异常结合分子。 SPR 技术的通量一般比 X 射线晶体学和核磁共振技术高出几个数量级。
1. 药物-靶标亲和力检测
2. 结合位点确认（竞争结合分析）
3. 化合物片段库筛选(基于片段的药物设计，FBDD)
4. 药物高通量筛选（HTS）
5. 中草药活性成分作用靶点确认
Fig. 1 Affinity measurement on a 340Da compound against target protein of virus infection process on CM5 sensor chip (Biacore T200). Partially published under authorization of end-user.
Fig. 2 Affinity measurement on a 340Da compound against target protein of virus infection process on CM5 sensor chip (Biacore T200). Partially published under authorization of end-user.
Fig. 3 Binding verification of a active compound extracted from TCM against a kinase target in human on CM5 sensor chip (Biacore T200), affinity KD=7.4 μM. Partially published under authorization of end-user.
Fig. 4 Binding verification of a active compound extracted from TCM against a kinase target in human on CM5 sensor chip (Biacore T200). affinity KD=7.4 μM . Partially published under authorization of end-user.
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