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抗体-Fc受体\补体结合分析


Fc receptor家族是IgG等抗体分子的效应受体,主要通过结合和介导IgG和白蛋白的跨屏障转运,从而延长抗体分子在血液中的半衰期。因此,FcRn与抗体分子的亲和力和动力学数据常用于表征抗体药物的代谢水平,是评价抗体成药性的重要指标。

抗体-Fc receptor\补体结合检测项目





Fig. 1 Kinetics measurement on bevacizumab biosimilar molecule against Human FcγRI receptor on CM5 sensor chip, and 2.57nM was determinated. (Biacore T200). Partially published under authorization of end-user.





Fig. 2 Kinetics measurement on bevacizumab biosimilar molecule against Human FcRn receptor on CM4 sensor chip, and 2.9μM was determinated. (Biacore T200). Partially published under authorization of end-user.

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